Most people in Eurasia today carry fragments of DNA inherited from ancient hominins such as Neanderthals and Denisovans. This genetic legacy has influenced traits such as immunity, skin pigmentation, and susceptibility to certain diseases, but the ways in which archaic DNA continues to shape human biology are still not fully understood.
The ARCH-3D project seeks to build three-dimensional models of Neanderthal and Denisovan genomes to study their spatial organisation. By comparing these models with those of modern humans, the research will aim to examine how introgressed regions affect gene regulation and contribute to human diversity.
Funder
Horizon Europe for MSCA Postdoctoral Fellowship
