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Department of Archaeology

 

Biography

My research uses population genetics to better understand human evolutionary history, including adaptation, genetic demography and archaic introgression. I am interested in how large-scale patterns of genetic variation, over countries and continents, are impacted by local social behaviours such as kinship practices, migration and movement decisions, and social hierarchies. I combine modelling and simulation with information from human genetics and other sources (linguistics, movement ecology, ancient DNA, domesticate genetics and the microbiome) to better understand these processes. My work has a regional focus in South Asia and island Southeast Asia.

 

Research

  • Human evolutionary genetics
  • Social behaviour and genetic diversity
  • Non-human and the microbiome
  • Hunter-gatherer genetic variation

I am presently involved in the following research projects:

  • 2018-2020: Archaic introgression and the evolution of modern humans
  • 2018-2020: Borneo Human Genome and Microbiome Diversity in Association with Health and Disease
  • 2019-2021: Pilot study of Cave Punan hunter-gatherers of Borneo

 

Publications

Key publications: 

 

N. N. Chung, G. S. Jacobs, H. Sudoyo, S. G. Malik, L. Y. Chew, J. S. Lansing and M. P. Cox 2019 “Sex-linked genetic diversity originates from persistent sociocultural processes at microgeographic scales” Royal Society Open Science 6(8):190733

G. S. Jacobs, G. Hudjashov et al 2019 “Multiple Deeply Divergent Denisovan Ancestries in Papuans” Cell 177(4):1010-1021

F. Mircea Iliescu, G. Chaplin, N. Rai, G. S. Jacobs, C. Basu Mallick, A. Mishra, K. Thangaraj and N. G. Jablonski 2018 “The influences of genes, the environment, and social factors on the evolution of skin color diversity in India” American Journal of Human Biology 5(30):e23170

J. S. Lansing, C. Abundo, G. S. Jacobs, E. G. Guillot, S. Thurner, S. S. Downey, L. Y. Chew, T. Bhattacharya, N. N. Chung, H. Sudoyo and M. P. Cox 2017 “Kinship structures create persistent channels for language transmission” PNAS 114(49):12910-12915

C. A. Eichstaedt et al 2017 “Evidence of early-stage selection on EPAS1 and GPR126 genes in Andean high altitude populations” Scientific Reports 7(13042) (Co-supervised this work)

C. E. Inchley et al 2016 “Selective sweep on human amylase genes postdates the split with Neanderthals” Scientific Reports 6:37198

G. S. Jacobs, T. J. Sluckin, T. Kivisild 2016 “Refining the use of linkage disequilibrium as a robust signature of selection” Genetics 203(4):1807-1825

L. Pagani et al 2016 “Genomic analyses inform on migration events during the peopling of Eurasia” Nature 538:238-242

G. S. Jacobs, T. J. Sluckin 2015 “Long-range dispersal, stochasticity, and the broken accelerating wave of advance” Theoretical Population Biology 100:39-55

G. A. Kaiping, G. S. Jacobs, S. J. Cox, T. J. Sluckin 2014 “Nonequivalence of updating rules in evolutionary games under high mutation rates” Physical Review E 90(4):042726     

F. J. Clemente et al 2014 “A Selective Sweep on a Deleterious Mutation in CPT1A in Arctic Populations” American Journal of Human Genetics 95(5):584-589

Teaching and Supervisions

Teaching: 

I am involved in the teaching of the following courses:

Paper B16 – Genomes: Ancient, modern and mixed

 

Research supervision: 

I am interested in supervising students who wish to study for an MPhil or a PhD in the following topics:

  • Genetics of archaic introgression
  • Genetic adaptation and signals of selection
  • Modelling the genetics of social behaviour
  • Human-domesticate coevolution
  • Genetics of South Asian cattle

Job Titles

Lecturer in Human Evolutionary Genetics and Bioinformatics
Image of Dr Guy Jacobs

General Info

Available for consultancy
Research Expertise / Fields of study: 
Human Population Genetics
Human Evolutionary and Behavioural Ecology

Contact Details

Affiliations

Subjects: 
Biological Anthropology
Geographical areas: 
South Asia
Southeast Asia